Background and objectives: Breast carcinoma of female is a leading cause of morbidity and mortality. Till date, a lot of studies have been carried out to find the accurate prognostic parameters of breast carcinoma to facilitate its treatment. In Asian population frequency of reactivity of some of these parameters like estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER-2) and E-cadherin receptor differs from the western population. As no more data are available on Bangladeshi population, this study was designed to find out the status of these receptors for this specific ethnic group.
Materials and methods: Total 86 histopathologically confirmed samples of breast carcinoma were included in this study. Histologically, they were divided into lobular and nonlobular category. Immunostain was done for ER, PR, HER-2 and E-cadherin receptor study. Statistical analysis was done to find out the association of these receptors with histological classification and grade.
Results: The mean age of the patients was 45.6 ± 10.7 years. Among histological subtype, total 9 (10.5%) found to be of lobular category and 77 (89.5%) were nonlobular type. Out of 86 patients, almost two third (61.6%) of patients were ER positive and 54.7% were PR positive. On the other hand 24 (27.9%) patients showed HER-2 overexpression and 79.1% patient showed E-cadherin positivity. About 64 (83.1%) nonlobular carcinoma was positive for E-cadherin. Only E-cadherin receptor showed significant association with histological classification.
Conclusion: It has been found that Bangladeshi population has lower rate of ER positivity when compared with the Western population and there is significant association between the histological type of breast carcinoma and E-cadherin receptor positivity.
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