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VOLUME 3 , ISSUE 1 ( January-March, 2020 ) > List of Articles

Original Article

Association of Insulin Resistance with Vitamin B12 Status in Type 2 Diabetes Mellitus Patients on Metformin Therapy

Cassinadane A Vayarvel, Vengatapathy Kuzhandai Velu, Shaik A Hussain, Ramesh Ramasamy

Keywords : Diabetes mellitus, Insulin resistant, Metformin, Vitamin B12

Citation Information : Vayarvel CA, Velu VK, Hussain SA, Ramasamy R. Association of Insulin Resistance with Vitamin B12 Status in Type 2 Diabetes Mellitus Patients on Metformin Therapy. 2020; 3 (1):16-18.

DOI: 10.5005/jp-journals-10082-02233

License: CC BY-NC 4.0

Published Online: 16-10-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Introduction: Association of insulin resistance with obesity and metabolic syndrome is an established fact. Vitamin B12 deficiency resulting from metformin therapy in type 2 diabetes mellitus (T2DM) patients was documented in the literature. In our study, we tried to explore the association of insulin resistance with vitamin B12 deficiency in T2DM patients on metformin therapy. Materials and methods: A total of 120 T2DM patients on metformin for at least 6 months with minimum dose of 1,000 mg/day between age group 35 years and 55 years were included. They were divided into group I (with B12 deficiency) and group II (with normal B12 levels). Patients who were on multivitamin supplementation or B12 therapy, nutritional deficiency of vitamin B12, or with any coexisting cause of B12 deficiency like alcoholism, liver, thyroid, and cardiac diseases were excluded from the study. Following biochemical parameters were estimated: fasting plasma glucose, fasting plasma insulin, and vitamin B12. Homocysteine and HOMO-IR were calculated. The statistical analysis, such as Student's t-test and Pearson correlation test, was performed. Results: B12 deficiency (group I) showed significant increase in insulin resistance. A negative correlation was observed between vitamin B12 and HOMA IR. Homocysteine showed positive correlation with HOMA IR. Conclusion: There is a negative correlation between the levels of vitamin B12 and insulin resistance and a positive correlation between homocysteine and insulin resistance in T2DM patients on metformin therapy.

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