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VOLUME 3 , ISSUE 1 ( January-March, 2020 ) > List of Articles

Original Article

Correlation of Lipid Profile with Duration of Diabetes and HbA1c Levels in Type 2 Diabetes Mellitus Patients: A Descriptive Cross-sectional Study

Shanmuga Priya, Nasreen Begum

Citation Information : Priya S, Begum N. Correlation of Lipid Profile with Duration of Diabetes and HbA1c Levels in Type 2 Diabetes Mellitus Patients: A Descriptive Cross-sectional Study. 2020; 3 (1):19-22.

DOI: 10.5005/jp-journals-10082-02234

License: CC BY-NC 4.0

Published Online: 01-08-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: HbA1c predicts the risk for the development of complications in patients with diabetes mellitus. The serum lipid profile of diabetic patients should be measured periodically to take suitable action based on age and type of disease. There exists a positive relationship between the HbA1c level and cardiovascular disease in nondiabetic cases even within the standard range of HbA1c. Numerous studies have been done to find the correlation between the blood glucose levels and parameters of the serum lipid profile. Aims: This study aims to estimate the serum lipid profile and HbA1c levels in type 2 diabetes mellitus (T2DM) and determine the associated factors including the duration of diabetes mellitus among type 2 diabetes mellitus of a tertiary care hospital in Tamil Nadu, India. Materials and methods: The cross-sectional study was done on 124 inpatients and outpatients in a tertiary care hospital, Tamil Nadu, India. Data were collected from the eligible patients on basic clinical details and blood investigations in the fasting state were assessed for FLP-total cholesterol, HDL, LDL, VLDL, TGL, HbA1c, CBC, urine routine, renal function test, and thyroid function test. Results: Eighty patients (64.5%) were having bad glycemic control based on HbA1c >7.5% and the remaining were having good glycemic control. Correlation of the lipid profile with duration of diabetes and HbA1c levels showed a significant positive correlation with total cholesterol, LDL, VLDL, and triglycerides. Correlation of other numerical variables such as age, HbA1c, and hemoglobin with duration of diabetes shows a significant positive correlation of age with HbA1c. Conclusion: Significant positive correlation of HbA1c with lipid profiles in our study suggests that HbA1c can also be used as a predictor of dyslipidemia in addition to a glycemic control parameter for prevention of complication.


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  1. Diabetes Foundation India. Diabetes Foundation (India) [Internet]. 2019 [cited 2019 Aug 19]. Available from: http://www.diabetesfoundationindia.org/about.htm#targetText=In India%2C about 50.9 million, Indo-US collaborative study).
  2. Ozder A. Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study. Lipids Health Dis 2014;13(1):183. DOI: 10.1186/1476-511X-13-183.
  3. Sreenivas Reddy A, Meera S, William E, Kumar JS. Correlation between glycemic control and lipid profile in type 2 diabetic patients: HbA1c as an indirect indicator of dyslipidemia. Asian J Pharm Clin Res 2014;7(2):153–155.
  4. Al-Alawi SA. Serum lipid profile and glycated hemoglobin status in omani patients with type 2 diabetes mellitus attending a primary care polyclinic. Biomed Res 2014;25(2):161–166.
  5. Baranwal JK, Maskey R, Majhi S, Lamsal M, Baral N. Association between level of HbA1c and lipid profile in T2DM patients attending diabetic OPD at BPKIHS. Heal Renaiss 2017;13(3):16–23. DOI: 10.3126/hren.v13i3.17923.
  6. Ravipati G, Aronow WS, Ahn C, Sujata K, Saulle LN, Weiss MB. Association of hemoglobin A1c level with the severity of coronary artery disease in patients with diabetes mellitus. Am J Cardiol 2006;97(7):968–969. DOI: 10.1016/j.amjcard.2005.10.039.
  7. Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 1973;19(5):476–482. DOI: 10.1093/clinchem/19.5.476.
  8. Deeg R, Ziegenhorn J. Kinetic enzymic method for automated determination of total cholesterol in serum. Clin Chem 1983;29(10):1798–1802. DOI: 10.1093/clinchem/29.10.1798.
  9. Hill JB, Kessler G. An automated determination of glucose utilizing a glucose oxidase-peroxidase system. J Lab Clin Med 1961;57: 970–980.
  10. Khaw KT, Wareham N, Bingham S, Luben R, Welch A, Day N. Association of hemoglobin A1c with cardiovascular disease and mortality in adults: the European prospective investigation into cancer in Norfolk. Ann Intern Med 2004;141(6):413–420. DOI: 10.7326/0003-4819-141-6-200409210-00006.
  11. Habiba NM, Fulda KG, Basha R, Shah D, Fernando S, Nguyen B, et al. Correlation of lipid profile and risk of developing type 2 diabetes mellitus in 10-14 year old children. Cell Physiol Biochem 2016;39(5):1695–1704. DOI: 10.1159/000447870.
  12. Moss. The association of glycemia and cause-specific mortality in a diabetic population. Arch Int Med 1994;154(21):2473–2477. DOI: 10.1001/archinte.1994.00420210113013.
  13. Nanaware M, Mankeshwar R. Assessment of long term glycaemic control (HbA1c) and its correlation with biochemical and other parameters in patients with type 2 diabetes mellitus in an urban community setting. Int J Med Sci 2017;6(2):239. DOI: 10.5455/ijmsph.2017.18072016585.
  14. Vinod Mahato R, Gyawali P, Raut PP, Regmi P, Singh KP, Pandeya DR, et al. Association between glycaemic control and lipid profile among type 2 diabetes patients: glycated haemoglobin as a dual marker. Biomed Res 2015;22(3):10–14.
  15. Arab AG, Zahedi M, Nejad VK, Sanagoo A, Azimi M. Correlation between hemoglobin A1c and serum lipid profile in type 2 diabetic patients referred to the diabetes clinic in Gorgan, Iran. Orig Res Artic JCBR 2018;2(1):26–31.
  16. Mahajan R, Koley S. Association of HbA1c with lipid profiles in patients with type 2 diabetes mellitus. Int J Biomed Res 2016;7(3): 139–143.
  17. Begum A, Irfan SR, Hoque MR, Habib SH, Parvin S, Malek R, et al. Relationship between HbA1c and lipid profile seen in Bangladeshi type 2 diabetes mellitus patients attending BIRDEM hospital: a cross-sectional study. Mymensingh Med J 2019;;28(1):91–95.
  18. Anand. Significance of HbA1c and lipid profile test in diagnosis and prognosis of diabetic and cardio-vascular patients. Int J Med Heal Res 2017;3(2):105–109.
  19. Bhattacharjee P, Das P, Nath BK, Basumatary A, Das D. HbA1C and its correlation with lipid profile in acute myocardial infarction. Int J Contemp Med Res 2018;5(4):13–16. DOI: 10.21276/ijcmr.2018.5.4.6.
  20. Valarmathi A, Sastri L. Glycosylated hemoglobin as a marker of dyslipidemia in type 2 diabetes mellitus patients in a tertiary care hospital. Int Arch Integr Med 2017;2(4):21–25.
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