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VOLUME 3 , ISSUE 2 ( April-June, 2020 ) > List of Articles

REVIEW ARTICLE

A Review of COVID-19 Clinical Presentation

Lokesh Shanmugam, Arvind Visweshwar

Citation Information : Shanmugam L, Visweshwar A. A Review of COVID-19 Clinical Presentation. 2020; 3 (2):44-46.

DOI: 10.5005/jp-journals-10082-02255

License: CC BY-NC 4.0

Published Online: 13-08-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

COVID-19 is a present pandemic infecting at exponential rates. Clinical presentations include fever, fatigue, myalgia, and dry cough; however, many atypical presentations have also been reported. COVID-19 is found to have cause pregnancy complications and is said to produce a multisystem inflammatory syndrome in children. This article is a review on clinical presentation of COVID-19 including its atypical presentation and presentation in pregnancy, children, and old age.


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  1. Weiss SR, Navas-Martin S. Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev 2005;69(4):635–664. DOI: 10.1128/MMBR.69.4.635-664.20055.
  2. World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 (Accessed on February 12, 2020).
  3. World Health Organization (WHO). WHO Director-General's opening remarks at the media briefing on COVID-19-11 March 2020. Available at: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19-11-march-2020 (Accessed on May 01, 2020).
  4. Chan JF-W, Yuan S, Kok K-H, To KK-W, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet Lond Engl 2020 15;395(10223):514–523. DOI: 10.1016/S0140-6736(20)30154-9.
  5. Guan W-J, Ni Z-Y, Hu Y, Liang W-H, Ou C-Q, He J-X, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708–1720. DOI: 10.1056/NEJMoa2002032.
  6. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020;382(13):1199–1207. DOI: 10.1056/NEJMoa2001316.
  7. Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med 2020;172(9):577–582. DOI: 10.7326/M20-0504.
  8. Liang W, Guan W, Chen R, Wang W, Li J, Xu K, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol 2020;21(3):335–337. DOI: 10.1016/S1470-2045(20)30096-6.
  9. Mehra MR, Desai SS, Kuy S, Henry TD, Patel AN. Cardiovascular disease, drug therapy, and mortality in COVID-19. N Engl J Med 2020;382(25):e102. DOI: 10.1056/NEJMoa2007621.
  10. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020;323(13):1239–1242. DOI: 10.1001/jama.2020.2648.
  11. Lighter J, Phillips M, Hochman S, Sterling S, Johnson D, Francois F, et al. Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clin Infect Dis 2020. ciaa415. DOI: 10.1093/cid/ciaa415.
  12. McMichael TM, Currie DW, Clark S, Pogosjans S, Kay M, Schwartz NG, et al. Epidemiology of COVID-19 in a long-term care facility in king county, Washington. N Engl J Med 2020;382(21):2005–2011. DOI: 10.1056/NEJMoa2005412.
  13. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the new york city area. JAMA 2020;323(20):2052–2059. DOI: 10.1001/jama.2020.6775[EPub Ahead of Print].
  14. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 2020;368:m1091.
  15. Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA 2020;323(18): 1775–1776. DOI: 10.1001/jama.2020.4683.
  16. Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol 2020. e200950. DOI: 10.1001/jamacardio.2020.0950.
  17. Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020. e200994. DOI: 10.1001/jamainternmed.2020.0994.
  18. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet Lond Engl 2020;395(10229):1054–1062. DOI: 10.1016/S0140-6736(20)30566-3.
  19. www.coronavirus.in.gov. (Accessed on May 01, 2020).
  20. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020;323(11):1061–1069. DOI: 10.1001/jama.2020.1585.
  21. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet Lond Engl 2020;395(10223):507–513. DOI: 10.1016/S0140-6736(20)30211-7.
  22. Colavita F, Lapa D, Carletti F, Lalle E, Bordi L, Marsella P, et al. SARS-CoV-2 isolation from ocular secretions of a patient with COVID-19 in Italy with prolonged viral RNA detection. Ann Intern Med 2020. M20–1176. DOI: 10.7326/M20-1176.
  23. Galván Casas C, Català A, Carretero Hernández G, Rodríguez-Jiménez P, Fernández Nieto D, Rodríguez-Villa Lario A, et al. Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. Br J Dermatol 2020. DOI: 10.1111/bjd.19163.
  24. Manalo IF, Smith MK, Cheeley J, Jacobs R. A dermatologic manifestation of COVID-19: transient livedo reticularis. J Am Acad Dermatol 2020;S0190-9622(20):30558. DOI: 10.1016/j.jaad.2020.05.001.
  25. Danzi GB, Loffi M, Galeazzi G, Gherbesi E. Acute pulmonary embolism and COVID-19 pneumonia: a random association? Eur Heart J 2020;41(19):1858. DOI: 10.1093/eurheartj/ehaa254.
  26. Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, et al. Guillain-Barré syndrome associated with SARS-CoV-2. N Engl J Med 2020;382(26):2574–2576. DOI: 10.1056/NEJMc2009191.
  27. Inciardi RM, Lupi L, Zaccone G, Italia L, Raffo M, Tomasoni D, et al. Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19). JAMA Cardiol 2020. DOI: 10.1001/jamacardio.2020.1096.
  28. Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP, et al. Large-vessel stroke as a presenting feature of COVID-19 in the young. N Engl J Med 2020;382(20):e60. NEJM [Internet]. [cited 2020 May 17]. Available from: https://www.nejm.org/doi/full/10.1056/NEJMc2009787.
  29. Elshafeey F, Magdi R, Hindi N, Elshebiny M, Farrag N, Mahdy S, et al. A systematic scoping review of COVID-19 during pregnancy and childbirth. Int J Gynaecol Obstet 2020. DOI: 10.1002/ijgo.13182.
  30. NYC Health. 2020 Health Alert #13: Pediatric multi-system inflammatory syndrome potentially associated with COVID-19. Available at: https://www1.nyc.gov/site/doh/providers/resources/health-alert-network.page (Accessed on May 07, 2020).
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