SBV Journal of Basic, Clinical and Applied Health Science

Register      Login

VOLUME 3 , ISSUE 2 ( April-June, 2020 ) > List of Articles

REVIEW ARTICLE

COVID-19: Microbiological Perspective

Subramanian Pramodhini, Subhash C Parija

Citation Information : Pramodhini S, Parija SC. COVID-19: Microbiological Perspective. 2020; 3 (2):65-69.

DOI: 10.5005/jp-journals-10082-02261

License: CC BY-NC 4.0

Published Online: 13-08-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Coronavirus-2019 (COVID-19), also named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a highly contagious disease, which has lead on to ongoing pandemic outbreak and now ended up in global public health emergency. This article will briefly review the morphology, genomic nature, and pathogenesis of this virus. In addition to it, brief description on laboratory diagnosis, approach to treatment, and preventive measures of COVID-19 based on various published research literature has been discussed.


PDF Share
  1. World Health Organization. Naming the coronavirus disease (COVID-19) and the virus that causes it. Geneva: WHO; 2020 [Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it. (mention the access date).
  2. World Health Organization. MERS situation update. 2019. http://applications.emro.who.int/docs/EMROPub_2019_MERA_apr_EN_23513.pdf (accessed on August 20,2019).
  3. Situation report by WHO on Novel Coronavirus (2019-nCoV) https://www.who.int/emergencies/diseases/novel-coronavirus- 2019.
  4. Salata C, Calistri A, Parolin C, Palu G. Coronaviruses: a paradigm of new emerging zoonotic diseases. Pathog Dis 2019;77(9):ftaa006. DOI: 10.1093/femspd/ftaa006.
  5. Brooks GF, Janet SB, Morse SA, Jawetz EJ. Melnick & Adelberg's Medical Microbiology. 28th ed., New York, N.Y.: Lange Medical Books/McGraw-Hill, Medical Pub. Division; 2019.
  6. Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol 2015;1282:1–23. DOI: 10.1007/978-1-4939-2438-7_1.
  7. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395(10223):507–513. DOI: 10.1016/S0140-6736(20) 30211-7.
  8. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet 2020;;395(10224):565–567. DOI: 10.1016/S0140-6736(20)30251-8.
  9. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020;8(4):420–422. DOI: 10.1016/S2213-2600(20)30076-X.
  10. World Health Organization. Coronavirus disease 2019 (COVID-19) situation report - 40. WHO; 2020.
  11. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of 2019 novel coronavirus infection in China. N Engl J Med 2020;382(18):1708–1720. DOI: 10.1056/NEJMoa2002032.
  12. Ministry of Health & Family Welfare, Government of India; 2020. Available from: https://mohfw.gov.in/node/4904, accessed on February 18, 2020.
  13. World Health Organization, Laboratory testing for coronavirus disease (COVID-19) in suspected human cases: interim guidance. WHO/COVID-19/laboratory/2020.5. Geneva: WHO; 2020. Available from: https://www.who.int/publications-detail/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases- 20200117.
  14. Centers for Disease Control and Prevention. CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel, Instructions for Use. Atlanta: CDC; 2020. Available from: https://www.fda.gov/media/134922/download.
  15. World Health Organization. Coronavirus disease (COVID-2019) situation reports. WHO; 2020. Available from: https://www.who.int/emergencies/diseases/novel coronavirus-2019/situation-reports, accessed on February 29, 2020.
  16. World Health Organization. Coronavirus disease (COVID-19) technical guidance: Laboratory testing for 2019-nCoV in humans. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/laboratory-guidance, accessed on February 29, 2020.
  17. Cheng PK, Wong DA, Tong LK, Ip SM, Lo AC, Lau CS, et al. Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome. Lancet 2004;363(9422):1699–1700. DOI: 10.1016/S0140-6736(04)16255-7.
  18. Zhang W, Du RH, Li B, Zheng XS, Yang XL, Hu B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect 2020;9(1):386–389. DOI: 10.1080/22221751.2020.1729071.
  19. Sethuraman N, Jeremiah SS, Ryo A. Interpreting diagnostic tests for SARS-CoV-2. JAMA 2020;323(22):2249–2251. DOI: 10.1001/jama.2020.8259.
  20. Lou B, Li T, Zheng S, Su Y, Li Z, Liu Wei, et al., Serology characteristics of SARS-CoV-2 infection since the exposure and post symptoms onset. medRxiv. Preprint posted March 27, 2020.
  21. National Task Force for Covid 19. Advisory on the use of Hydroxy-chloroquine as prophylaxis for SARS-CoV-2 infection. New Delhi: ICMR; 2020 March 22 [cited 2020 Apr 14]. Available from: https://icmr.nic.in/sites/default/files/upload_documents/HCQ_Recommendation_22March_final_MM_V2.pdf.
  22. Thanh LeT, Andreadakis Z, Kumar A, Gómez Román R, Tollefsen S, Saville M, et al. The COVID-19 vaccine development landscape. Nat Rev Drug Discov 2020;19(5):305–306. DOI: 10.1038/d41573-020-00073-5.
  23. Chen WH, Strych U, Hotez PJ, Bottazzi ME. The SARS-CoV-2 vaccine pipeline: an overview. Curr Trop Med Rep 2020(2):1–4. DOI: 10.1007/s40475-020-00201-6.
  24. Update on WHO Solidarity Trial – Accelerating a safe and effective COVID-19 vaccine”. World Health Organization. 27 April 2020. accessed on 2 May 2020.
  25. Vaccine Safety - Vaccines” (https://www.vaccines.gov/basics/safety). www.vaccines.gov. US Department of Health and Human Services. accessed on 13 April 2020.
  26. “The drug development process” (https://www.fda.gov/patients/learn-about-drug-and-device-approvals/drug-development-process). US Food and Drug Administration. 4 January 2018. accessed on 12 April 2020.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.