Efficacy of 2% Chitosan Mouthwash on Plaque Reduction in Comparison with 0.2% Chlorhexidine Mouthwash among Young Adults: A Triple-blinded Crossover Randomized Controlled Trial
Citation Information :
Baskaran NG, Divvi A, Murugappan S, Kengadaran S, Murugaboopathy V, Gunasekaran V. Efficacy of 2% Chitosan Mouthwash on Plaque Reduction in Comparison with 0.2% Chlorhexidine Mouthwash among Young Adults: A Triple-blinded Crossover Randomized Controlled Trial. 2021; 4 (2):35-38.
Aim and objective: The purpose of this study was to assess the 2% chitosan mouthwash on plaque reduction in comparison with 0.2% chlorhexidine mouthwash among young adults in Puducherry.
Materials and methods: A triple-blinded crossover randomized controlled trial was conducted among 20 first-year dental students, residing at college hostel in Puducherry. The subjects were randomly allotted to two groups (group I: 2% chitosan mouthwash and group II: 0.2% chlorhexidine mouthwash) with 10 subjects in each group. The plaque index proposed by Silness and Loe in 1967 was used for the assessment of plaque accumulation at baseline and 1 week after using mouthwashes. After a washout period of 30 days, mouthwashes were exchanged between the two groups, and plaque index was recorded. Data were assessed using an independent t-test and paired t-test.
Results: A significant reduction in plaque index scores was observed from baseline to 1 week following intervention (p <0.05) in both the groups during both phases. However, there was no significant difference between the two groups in plaque reduction (p >0.05).
Conclusion: This study reveals that 2% chitosan mouthwash is as effective as 0.2% chlorhexidine mouthwash, thereby warranting the use of the chitosan mouthwash for managing patients who show side effects associated with chlorhexidine.
Dwarakanath CD. Carranza's clinical periodontology-ebook: third South Asia edition. Elsevier Health Sciences; 2019.
Harris NO, Garcia-Godoy F. Primary preventive dentistry. Upper Saddle River, NJ: Pearson Education; 2013.
Jafer M, Patil S, Hosmani J, Bhandi SH, Chalisserry EP, Anil S. Chemical plaque control strategies in the prevention of biofilm-associated oral diseases. J Contemp Dent Pract 2016;17(4):337–343. DOI: 10.5005/jp-journals-10024-1851.
Anusha D, Chaly PE, Junaid M, Nijesh JE, Shivashankar K, Sivasamy S. Efficacy of a mouthwash containing essential oils and curcumin as an adjunct to nonsurgical periodontal therapy among rheumatoid arthritis patients with chronic periodontitis: a randomized controlled trial. Indian J Dent Res 2019;30(4):506–511. DOI: 10.4103/ijdr.IJDR_662_17.
Costa EM, Silva S, Madureira AR, Cardelle-Cobas A, Tavaria FK, Pintado MM. A comprehensive study into the impact of a chitosan mouthwash upon oral microorganism's biofilm formation in vitro. Carbohydr Polym 2014;101:1081–1086. DOI: 10.1016/j.carbpol.2013.09.041.
De Carvalho MM, Stamford TC, Pereira E, Dos Santos P, Sampaio F. Chitosan as an oral antimicrobial agent. Formatex 2011;2012(1):13. http://dx.doi:org/10.18203/2319-2003.ijbcp20194777
Löe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol 1967;38(6):Suppl:610–616. DOI: 10.1902/jop.1967.38.6.610.
Jones CG. Chlorhexidine: is it still the gold standard?. Periodontology 2000. 1997;15:55–62. DOI: 10.1111/j.1600-0757.1997.tb00105.x.
Thomas A, Thakur SR, Shetty SB. Anti-microbial efficacy of green tea and chlorhexidine mouth rinses against Streptococcus mutans, Lactobacilli spp. and Candida albicans in children with severe early childhood caries: a randomized clinical study. J Indian Soc Pedod Prev Dent 2016;34(1):65. DOI: 10.4103/0970-4388.175518.
Decker EM, Weiger R, Wiech I, Heide PE, Brecx M. Comparison of antiadhesive and antibacterial effects of antiseptics on Streptococcus sanguinis. Eur J Oral Sci 2003;111(2):144–148. DOI: 10.1034/j.1600-0722.2003.00025.x.
Uraz A, Boynueğri D, Özcan G, Karaduman B, Uc D, Şenel S, et al. Two percent chitosan mouthwash: a microbiological and clinical comparative study. J Dent Sci 2012;7(4):342–349. DOI: 10.1016/j.jds.2012.05.003.
