Background: HbA1c predicts the risk for the development of complications in patients with diabetes mellitus. The serum lipid profile of diabetic patients should be measured periodically to take suitable action based on age and type of disease. There exists a positive relationship between the HbA1c level and cardiovascular disease in nondiabetic cases even within the standard range of HbA1c. Numerous studies have been done to find the correlation between the blood glucose levels and parameters of the serum lipid profile. Aims: This study aims to estimate the serum lipid profile and HbA1c levels in type 2 diabetes mellitus (T2DM) and determine the associated factors including the duration of diabetes mellitus among type 2 diabetes mellitus of a tertiary care hospital in Tamil Nadu, India. Materials and methods: The cross-sectional study was done on 124 inpatients and outpatients in a tertiary care hospital, Tamil Nadu, India. Data were collected from the eligible patients on basic clinical details and blood investigations in the fasting state were assessed for FLP-total cholesterol, HDL, LDL, VLDL, TGL, HbA1c, CBC, urine routine, renal function test, and thyroid function test. Results: Eighty patients (64.5%) were having bad glycemic control based on HbA1c >7.5% and the remaining were having good glycemic control. Correlation of the lipid profile with duration of diabetes and HbA1c levels showed a significant positive correlation with total cholesterol, LDL, VLDL, and triglycerides. Correlation of other numerical variables such as age, HbA1c, and hemoglobin with duration of diabetes shows a significant positive correlation of age with HbA1c. Conclusion: Significant positive correlation of HbA1c with lipid profiles in our study suggests that HbA1c can also be used as a predictor of dyslipidemia in addition to a glycemic control parameter for prevention of complication.