COVID-19, being a dreadly viral infection, has put the entire globe in a pandemic situation in the present scenario. The RNA virus was first reported in later 2019; various diagnostic modalities are applied including polymerase chain reaction (PCR) since PCR detects RNA viruses and their strain. Though many theories had been proposed and accepted worldwide, the path and sequelae of COVID-19 is debatable especially after the release of the autopsy analysis conducted at Italy, the results of which turned out to be a revolutionary tool in managing COVID-19 patients. The coronavirus could be classified based on its characteristics into many types such as O, A2, A2a, A3, B, B1, totally numbering to 11 strains. It has been proved by research studies including an Indian institute's study that “A2a” strain is the most predominant and virulent strain. The basic pathogenic molecular mechanism of SARS-Cov2 is by entering the lung system and cells and disrupting the 1-β chain of hemoglobin and extracting out the porphyrin rings and dissociating the iron content from it, thereby releasing iron into the circulation. The increased Hb production eventually leads to increase in the blood viscosity level with recurrent and diffuse micro- and macrocirculatory thrombosis in the form of blood clot, the major underlying reason substantiating the elevated levels of D-dimer among the infected patients and thus explaining the cause of sudden deterioration and death. COVID-19 management warrants a multidimensional approach in management, and judicious laboratory diagnosis plays a vital role in picking up the infected cases. Scientific reviews throws light on the primary underlying pathophysiology, thereby redirecting the mode of approach and subsequent management and proclaiming that the grave condition is associated with disseminated intravascular coagulation with microthrombi warranting rationale treatment with anti-inflammatory and anti-coagulant drugs rather than empirical and irrational usage of mechanical ventilators.