Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. COVID-19 has been associated with a wide range of opportunistic infections, viz. bacterial and fungal. Mucormycosis is one of the most deadly and life-threatening invasive fungal infections which has typically seen a rising trend with the rise in COVID-19 cases. Patients who are at higher risk to develop mucormycosis include those with uncontrolled diabetes mellitus, steroid-induced immunosuppression, acquired immunodeficiency syndrome, immunosuppression due to malignancies or posttransplant, prolonged stay in intensive care units, patients on oxygen therapy and/or mechanical ventilation, etc. Preventive strategies for mucormycosis should aim at addressing the underlying risk factors in COVID-19 patients, airborne infection control at the facility level, as well as personal protective measures at the individual level. Finally, a high index of suspicion, clinically, on the part of the treating physician can go a long way in prompt diagnosis and initiation of aggressive antifungal therapy and extensive surgical management of mucormycosis, leading to an improved outcome.
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