Lung cancer is one of the most common cancers that causes death. Autofluorescence bronchoscopy is a recent technology which uses blue light to detect precancerous lesions that cannot be detected by conventional white light bronchoscopy. This is based on the principle that there is difference in emission of this light between premalignant and malignant tissue, that can be distinguished by a change in color emitted. Advantage of autofluorescence bronchoscopy is that it has excellent sensitivity in picking up abnormal tissues; therefore, early detection of cancers can be made, and appropriate treatment can be given, thereby increasing the survival. The major drawback of this procedure is that it lacks specificity.
Greenlee RT, Murray T, Bolden S, Wingo PA. Cancer Statistics 2000. CA Cancer J Clin 2000;50(1):7–33. DOI: 10.3322/canjclin.50.1.7.
Woolner LB, Fontana RS, Cortese DA, Sanderson DR, Bernatz PE, Payne WS, et al. Roentgenographically occult lung cancer: pathologic findings and frequency of multicentricity during a 10-year period. Mayo Clin Proc 1984;59(7):453–466. DOI: 10.1016/s0025-6196(12)60434-0.
Sutedja TG, Codrington H, Risse EK, Breuer RH, van Mourik JC, Golding RP, et al. Autofluorescence bronchoscopy improves staging of radiographically occult lung cancer and has an impact on therapeutic strategy. Chest 2001;120(4):1327–1332. DOI: 10.1378/chest.120.4.1327.
Crymes TP, Fish RG, Smith DE. Autofluorescence Bronchoscopy Definition Autofluorescence bronchoscopy is a bronchoscopic procedure in which a blue light rather than a white light is employed for illumination, and prema. CHEST 2003;123:1701. https://doi.org/10.1016/S0012-3692(15)33711-9.
Hung J, Lam S, LeRiche JC, Palcic B. Autofluorescence of normal and malignant bronchial tissue. Lasers Surg Med 1991;11:99. DOI: 10.1002/lsm.1900110203.
Mahmoud N, Vashisht R, Sanghavi D, Kalanjeri S. Bronchoscopy. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448152/.
Edell E, Lam S, Pass H, Miller YE, Sutedja T, Kennedy T, et al. Detection and localization of intraepithelial neoplasia and invasive carcinoma using fluorescence-reflectance bronchoscopy: an international, multicenter clinical trial. J Thorac Oncol 2009;4(1):49–54. DOI: 10.1097/JTO.0b013e3181914506.