Research, a methodical pathway to discover facts, enunciate principles, or offer an interpretation of the existing knowledge. Everything written in undergraduate textbooks was once a research topic, somebody thought about a relation, or correlation, and asked a question, and research was the path to the answer. To start any research, students should be aware of the right time and methods. The best way to start research from scratch is to approach the respective college or department. Showing enthusiasm or zeal to know may help pave your way into it. Having a mentor at the college is of great help. With the ever-changing face of medicine in today's rapidly changing world, it is of utmost importance to prepare for the upcoming challenges; research is our biggest tool in this. To conclude, medical research is at crossroads and is being scrutinized for validity and reproducibility. Errors are common, but can jeopardize the health of a number of people. Sloppy research is waste of time and resources. It plays a crucial role in discovering new treatments, while making sure that we use existing treatments in the best possible ways. Research helps us to explore the unknown, filling the gaps in existing knowledge and modifying the way that health care professionals work.