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VOLUME 6 , ISSUE 2 ( April-June, 2023 ) > List of Articles


Potassium-competitive Acid Blocker: A Newer Target in the Treatment of Acid Peptic Disorder

Navinraja Komal Veererathinakumar, Vimala Ananthy, R Sudar Codi, K Manimekalai

Keywords : Acid peptic disorders, H+K+-ATPase (proton pump), Proton-pump inhibitors, Potassium-competitive acid blocker, Vonoprazan

Citation Information : Veererathinakumar NK, Ananthy V, Codi RS, Manimekalai K. Potassium-competitive Acid Blocker: A Newer Target in the Treatment of Acid Peptic Disorder. 2023; 6 (2):33-38.

DOI: 10.5005/jp-journals-10082-03182

License: CC BY-NC 4.0

Published Online: 13-04-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Acid peptic disorders are a group of disorders that include gastroesophageal reflux disease, gastric ulcer, and duodenal ulcer. The most common causes are nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori infection. If not treated adequately, it may lead to life-threatening complications like gastrointestinal bleeding and intestinal perforation. H+K+-ATPase enzyme in parietal cells is involved in the final step of gastric acid secretion through a conformational change from E1 to E2 form. Proton-pump inhibitors (PPIs) are commonly used drugs for the treatment of acid peptic disorders. Proton-pump inhibitors have some limitations such as irreversible inhibition, it is a prodrug. Continuous attempts are made to develop newer targets that overcome these limitations of PPIs in treating acid peptic disorders. Vonoprazan, a novel potassium-competitive acid blocker (P-CAB) approved by the FDA for H. pylori infection in combination with antibiotics, could be a potential alternative to PPI in the management of acid peptic disorders. This review mainly highlights the pharmacology of Vonoprazan.

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