Background: Adverse drug reactions (ADRs) are common occurrences in a hospital setting attributed to the severity and complexity of the disease process, use of multiple drugs, drug interactions, and possible negligence. Chloroquine-induced photosensitive dermatoses refer to skin conditions that arise as a result of sensitivity to sunlight or ultraviolet (UV) radiation after the use of chloroquine medication. Methods: We report a case of photosensitive dermatoses due to chloroquine is seen in a tertiary care teaching hospital at Puducherry. Results: A fifty years old female patient was prescribed chloroquine 150 mg orally for a period of 1 month for rheumatoid arthritis. At the end of 1 month, she developed multiple, irregular, well-defined, pigmented, scaly plaques over the sun-exposed areas of the face, upper arms, and forearms. A diagnosis of probable chloroquine-induced photosensitive dermatitis was made. Conclusion: Chloroquine-induced photodermatoses are an uncommon adverse drug reaction seen in 1–2% of the population. Though routine ophthalmological examination is done for patients on chloroquine therapy, this adverse cutaneous drug reaction should also be looked at with caution by the prescribing physicians.